Synthesis and applications of Fe 3 O 4 -diisopropylaminoacetamide as a versatile and reusable magnetic nanoparticle supported N , N -diisopropylethylamine equivalent
Parintip Rattanaburi , Bannarak Khumraksa , Mookda Pattarawarapan
Graphical abstract ;;Abstract A magnetic neodymium magnet nanoparticle supported N,N -diisopropylaminoacetamide (Fe 3 O 4 -DIPA) was developed for application as a magnetic recoverable, and reusable N,N -diisopropylethylamine equivalent. The Fe 3 O 4 nanoparticles were coated with a silica layer using the sol-gel method, followed by surface modification with 3-aminopropyltriethoxysilane. Subsequent acylation with chloroacetyl chloride and chlorine d ...isplacement with diisopropylamine afforded Fe 3 O 4 -DIPA in 90% yield with a loading of 0.96mmol/g. The applicability of Fe 3 O 4 -DIPA was demonstrated in the synthesis of amine derivatives cv sulfonation, acylation, and N-alkylation reactions. The desired products were obtained in excellent yields and purities after scavenging the residual starting amines by treatment with silica-supported dichlorotriazine. Fe 3 O 4 -DIPA was readily recovered by separation using a magnet and could be reused several times without significant loss of reactivity.
